Abstract
Prevailing theories hold that the insula is functionally organized along its caudal-to-rostral axis, with posterior regions coding lower-level sensory information and anterior regions coding higher-level stimulus significance relative to the body's homeostatic needs. Contrary to predictions of this model, the response of the taste-sensitive region of the caudal, but not rostral, insula to food images was directly related to the body's homeostatic state as indexed by levels of peripheral glucose.
Trial registration:
ClinicalTrials.gov NCT00846040.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Afferent Pathways / blood supply
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Afferent Pathways / physiology*
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Blood Glucose / physiology
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Brain Mapping*
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Cerebral Cortex / blood supply
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Cerebral Cortex / physiology*
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Female
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Homeostasis / physiology*
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Humans
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Image Processing, Computer-Assisted
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Magnetic Resonance Imaging
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Male
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Oxygen
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Photic Stimulation
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Taste / physiology*
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Young Adult
Associated data
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ClinicalTrials.gov/NCT00846040