1 INSERM U657 & CIC-P0005, Univ Bordeaux, Bordeaux, France, nicholas.moore@pharmaco.u-bordeaux2.fr INSERM CIC-P0005, Univ Bordeaux, Bordeaux, France INSERM CIC-P0005, ADERA, Bordeaux, France INSERM U657, Bordeaux, France CHU de Montpellier, Montpellier, France INSERM U657, Rouen, France.