Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease

J Pediatr. 2014 Jan;164(1):186-8. doi: 10.1016/j.jpeds.2013.07.050. Epub 2013 Sep 21.

Abstract

Management of pediatric chronic liver disease is limited by lack of validated noninvasive biomarkers of histologic severity. We demonstrate that magnetic resonance elastography is feasible and accurate in detecting significant hepatic fibrosis in a case series of 35 children with chronic liver disease, including severely obese children.

Keywords: ARFI; AUROC; Acoustic radiation force imaging; Area under the receiver operating characteristic curve; BMI; Body mass index; MRE; Magnetic resonance elastography; NAFLD; NASH; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; ROI; Region of interest; TE; Transient elastography; US; Ultrasound.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Chronic Disease
  • Elasticity Imaging Techniques / methods*
  • Elasticity Imaging Techniques / statistics & numerical data
  • Female
  • Humans
  • Liver Cirrhosis / diagnosis*
  • Liver Cirrhosis / etiology
  • Liver Diseases / complications
  • Liver Diseases / diagnosis
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / statistics & numerical data
  • Male
  • ROC Curve
  • Reproducibility of Results
  • Retrospective Studies
  • Severity of Illness Index
  • Young Adult