[Recent progress in multi-stage mass spectrometry-based quantitative proteomics]

Se Pu. 2013 Jun;31(6):503-9. doi: 10.3724/sp.j.1123.2013.03056.
[Article in Chinese]

Abstract

With the development of proteome research, quantitative proteomics is becoming a very active area of proteomics research. The development of quantitative proteomics requires the advancement of a number of mass spectrometry (MS) -based quantitative techniques. According to the mass spectrometric stage at which the peptides are quantified, MS-based quantitative methods can be divided into two categories: MS(1) -based quantitation and MS(n)-based quantitation. In this review, the progress of MS(n)-based quantitation approaches is summarized and the advantages and disadvantages are compared. The trend of MS(n)-based quantitation is also prospected.

Publication types

  • Review

MeSH terms

  • Mass Spectrometry*
  • Peptides
  • Proteome
  • Proteomics / methods*

Substances

  • Peptides
  • Proteome