Preparation of polymer gel dosimeters based on less toxic monomers and gellan gum

Phys Med Biol. 2013 Oct 21;58(20):7131-41. doi: 10.1088/0031-9155/58/20/7131. Epub 2013 Sep 20.

Abstract

New polymer gel dosimeters consisting of 2-hydroxyethyl methacrylate (HEMA), triethylene glycol monoethyl ether monomethacrylate (TGMEMA), polyethylene glycol 400 dimethacrylate (9G), tetrakis (hydroxymethyl) phosphonium chloride as an antioxidant, and gellan gum as a gel matrix were prepared. They were optically analyzed by measuring absorbance to evaluate a dose response. The absorbance of the polymer gel dosimeters that were exposed to (60)Co γ-rays increased with increasing dose. The dosimeters comprising HEMA and 9G showed a linear increase in absorbance in the dose range from 0 to 10 Gy. The dose response depended on the 9G concentration. For others comprising HEMA, 9G and TGMEMA, the absorbance of the polymer gel dosimeters drastically increased above a certain dose, and then leveled off up to 10 Gy. The optical variations in these polymer gel dosimeters were also induced by x-irradiation from Cyberknife radiotherapy equipment. Furthermore, the exposed region of the latter polymer gel dosimeter exhibited a thermo-responsive behavior.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gels
  • Methacrylates / chemistry
  • Polymers / adverse effects*
  • Polymers / chemistry*
  • Polysaccharides, Bacterial / chemistry*
  • Radiation Dosage
  • Radiometry / methods*
  • Safety

Substances

  • Gels
  • Methacrylates
  • Polymers
  • Polysaccharides, Bacterial
  • methacrylic acid
  • gellan gum