First trimester maternal serum vitamin D and markers of preeclampsia

J Matern Fetal Neonatal Med. 2014 Jul;27(10):1078-9. doi: 10.3109/14767058.2013.846318. Epub 2013 Nov 7.

Abstract

Objective: There is evidence that vitamin D deficiency is associated with preeclampsia. The aim of the study was to determine if maternal levels of vitamin D at 1st trimester were related to markers of preeclampsia.

Material: Serum levels of 25-hydroxy-vitamin D (25OHD), PAPP-A, PlGF, uterine artery pulsatility index and mean arterial pressure were measured in 280 pregnant women.

Results: Preeclampsia markers were not related to 25OHD concentration.

Conclusion: First trimester maternal serum concentration of vitamin D does not seem to be connected with markers of preeclampsia.

Keywords: Mean artery pressure; PAPP-A; PlGF; preeclampsia; pregnancy; uterine artery pulsatility index; vitamin D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Female
  • Humans
  • Placenta Growth Factor
  • Pre-Eclampsia / blood
  • Pre-Eclampsia / diagnosis
  • Pre-Eclampsia / etiology*
  • Pregnancy
  • Pregnancy Proteins / blood
  • Pregnancy Trimester, First / blood*
  • Pregnancy-Associated Plasma Protein-A / metabolism
  • Risk Factors
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / diagnosis

Substances

  • Biomarkers
  • PGF protein, human
  • Pregnancy Proteins
  • Vitamin D
  • Placenta Growth Factor
  • 25-hydroxyvitamin D
  • Pregnancy-Associated Plasma Protein-A