DEFB1 gene 5' untranslated region (UTR) polymorphisms are marginally involved in inflammatory bowel disease in south Brazilians

T J Wilson; M Jobim; L Segat; A M Bianco; P H Salim; P Portela; L F Jobim; D C Damin; G Schwartsmann; R Roesler; S Crovella

doi:10.1111/iji.12089

DEFB1 gene 5' untranslated region (UTR) polymorphisms are marginally involved in inflammatory bowel disease in south Brazilians

Int J Immunogenet. 2014 Apr;41(2):138-42. doi: 10.1111/iji.12089. Epub 2013 Sep 12.

Authors

T J Wilson¹, M Jobim, L Segat, A M Bianco, P H Salim, P Portela, L F Jobim, D C Damin, G Schwartsmann, R Roesler, S Crovella

Affiliation

¹ Department of Immunology, Hospital de Clínicas, Porto Alegre, Brazil.

PMID: 24034632
DOI: 10.1111/iji.12089

Abstract

The possible association of three DEFB1 gene polymorphisms with susceptibility to develop ulcerative colitis (UC) and Crohn's disease (CD) was investigated in Brazilian patients and controls. Although a clear and strong association between functional 5'-UTR DEFB1 SNPs and susceptibility/protection to IBDs cannot be drawn, our results suggest a possible involvement of DEFB1 gene in inflammatory bowel diseases, especially with the colonic localization of Crohn's disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

5' Untranslated Regions*
Adult
Brazil
Case-Control Studies
Colitis, Ulcerative / genetics
Crohn Disease / genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Inflammatory Bowel Diseases / genetics*
Male
Polymorphism, Single Nucleotide
beta-Defensins / genetics*

Substances

5' Untranslated Regions
DEFB1 protein, human
beta-Defensins