Post-chemotherapy maturation in supratentorial primitive neuroectodermal tumors

Lucie Lafay-Cousin; Walter Hader; Xing Chang Wei; Robert Nordal; Douglas Strother; Cynthia Hawkins; Jennifer A Chan

doi:10.1111/bpa.12089

Post-chemotherapy maturation in supratentorial primitive neuroectodermal tumors

Brain Pathol. 2014 Mar;24(2):166-72. doi: 10.1111/bpa.12089. Epub 2013 Nov 27.

Authors

Lucie Lafay-Cousin¹, Walter Hader, Xing Chang Wei, Robert Nordal, Douglas Strother, Cynthia Hawkins, Jennifer A Chan

Affiliation

¹ Division of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital, Calgary, Alberta, Canada.

Abstract

Maturation in central nervous system embryonal tumors is an uncommon phenomenon that is mainly reported in the context of specific histological subgroups of medulloblastoma. In this report we describe two cases of histological maturation in patients with supratentorial primitive neuroectodermal tumor with strikingly different outcomes. We discuss the potential impact of such findings on treatment and outcome.

Keywords: ETANTR; ETMR; maturation; prognosis; sPNET.

Publication types

Case Reports

MeSH terms

Brain Neoplasms / drug therapy
Brain Neoplasms / pathology*
Female
Humans
Infant
Neuroectodermal Tumors, Primitive / drug therapy
Neuroectodermal Tumors, Primitive / pathology*
Supratentorial Neoplasms / drug therapy
Supratentorial Neoplasms / pathology*