Responsible conduct of research (RCR) education is now common throughout the United States, primarily in response to federal requirements beginning with the National Institutes of Health in 1989. Despite this long history, RCR education programs remain highly disparate, often with ill-defined content, format, and goals, and minimal evidence for effectiveness. However because it is widely believed that such programs can have value, it is hoped that a review of what is available, and how that came to pass, will highlight what has been done well and where gaps still remain.