Gardovatine, a novel Strychnos-Strychnos bisindole alkaloid with cytotoxicity from Gardneria oveta

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5563-5. doi: 10.1016/j.bmcl.2013.08.051. Epub 2013 Aug 16.

Abstract

Gardovatine (1), the first Strychnos-Strychnos alkaloid with a C3/C7 cleaved backbone, was isolated from twigs and leaves of Gardneria ovate, together with an analogue divarine (2). The structure was established by extensive spectroscopic methods. Both compounds showed potential cytotoxicities against five human cancer cell lines.

Keywords: Cytotoxicity; Gardneria ovata; Gardovatine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Alkaloids / toxicity
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Indole Alkaloids / chemistry*
  • Indole Alkaloids / isolation & purification
  • Indole Alkaloids / toxicity
  • Indoles / chemistry*
  • Loganiaceae / chemistry*
  • Loganiaceae / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Plant Leaves / chemistry
  • Plant Leaves / metabolism
  • Strychnos / chemistry*
  • Strychnos / metabolism

Substances

  • Alkaloids
  • Indole Alkaloids
  • Indoles
  • divarine
  • gardovatine
  • indole