Abstract
We examined the association of filaggrin loss-of-function mutations in U.S. atopic patients with asthma. We confirm that only Whites with the R501X mutation and AD have increased risk of asthma.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Asthma / complications*
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Asthma / epidemiology*
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Asthma / genetics
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Dermatitis, Atopic / complications*
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Female
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Filaggrin Proteins
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Humans
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Intermediate Filament Proteins / genetics
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Male
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Mutation
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Odds Ratio
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United States / epidemiology
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United States / ethnology
Substances
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FLG protein, human
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Filaggrin Proteins
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Intermediate Filament Proteins