The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites

Mol Cell Biol. 1990 Oct;10(10):5580-5. doi: 10.1128/mcb.10.10.5580-5585.1990.

Abstract

Glucocorticoid receptor mRNA is regulated by glucocorticoids. We found no consensus glucocorticoid response element, TATA box, or CAAT box but many GC boxes in approximately 3 kilobases of the 5'-flanking sequence of the human glucocorticoid receptor gene. We identified several transcription start sites, an untranslated exon 1, and the coding content of exon 2.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Exons
  • Gene Expression Regulation
  • Humans
  • Molecular Sequence Data
  • Promoter Regions, Genetic*
  • RNA, Messenger / genetics
  • Receptors, Glucocorticoid / genetics*
  • Regulatory Sequences, Nucleic Acid*
  • Transcription, Genetic

Substances

  • RNA, Messenger
  • Receptors, Glucocorticoid

Associated data

  • GENBANK/M32284