Evaluation of the Influence of thiosemicarbazone-triazole hybrids on genes implicated in lipid oxidation and accumulation as potential anti-obesity agents

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5275-8. doi: 10.1016/j.bmcl.2013.08.028. Epub 2013 Aug 13.

Abstract

A series of thiosemicarbazone-triazole hybrids 1a-h are efficiently synthesised and evaluated for their influence on the expression of genes, cpt-1, acc-1 and pgc-1, which are essential in lipid metabolism. The test results show that hybrids 1c and 1g exhibited relatively high influence on the expression of cpt-1 and pgc-1 and suppression of acc-1 as desired.

Keywords: Diabetics; Lipid; Obesity; Thiosemicarbazon–triazole hybrid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Obesity Agents* / chemistry
  • Anti-Obesity Agents* / pharmacology
  • Gene Expression / drug effects
  • Humans
  • Lipid Metabolism / drug effects
  • Molecular Structure
  • Thiazoles* / chemical synthesis
  • Thiazoles* / pharmacology
  • Thiosemicarbazones* / chemical synthesis
  • Thiosemicarbazones* / pharmacology

Substances

  • Anti-Obesity Agents
  • Thiazoles
  • Thiosemicarbazones