Group A streptococcal emm type prevalence among symptomatic children in Cape Town and potential vaccine coverage

Pediatr Infect Dis J. 2014 Feb;33(2):208-10. doi: 10.1097/INF.0b013e3182a5c32a.

Abstract

The molecular epidemiology of group A streptococcal pharyngeal infections in children in the Vanguard Community of Cape Town revealed 26 emm types among 157 isolates from 742 subjects. Coverage of a 30-valent vaccine is predicted to be 95% of pharyngitis cases in this population at high risk of rheumatic fever.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antigens, Bacterial / genetics*
  • Antigens, Bacterial / immunology
  • Bacterial Outer Membrane Proteins / genetics*
  • Bacterial Outer Membrane Proteins / immunology
  • Carrier Proteins / genetics*
  • Carrier Proteins / immunology
  • Child
  • Child, Preschool
  • Humans
  • Molecular Epidemiology
  • Pharyngitis / epidemiology
  • Pharyngitis / microbiology
  • Prevalence
  • Rheumatic Fever
  • South Africa / epidemiology
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / microbiology*
  • Streptococcal Infections / prevention & control
  • Streptococcal Vaccines / administration & dosage*
  • Streptococcus pyogenes / genetics
  • Streptococcus pyogenes / immunology*
  • Streptococcus pyogenes / isolation & purification*

Substances

  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Carrier Proteins
  • Streptococcal Vaccines
  • streptococcal M protein