Abstract
The development of a practical, asymmetric synthesis of the hepatitis C virus (HCV) protease inhibitor MK-5172 (1), an 18-membered macrocycle, is described.
MeSH terms
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Amides
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Carbamates
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Cyclopropanes
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Hepacivirus / drug effects*
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Macrocyclic Compounds / chemical synthesis*
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Macrocyclic Compounds / chemistry
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Macrocyclic Compounds / pharmacology*
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Molecular Structure
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Protease Inhibitors / chemical synthesis*
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Protease Inhibitors / chemistry
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Protease Inhibitors / pharmacology*
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Quinoxalines / chemical synthesis*
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Quinoxalines / chemistry
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Quinoxalines / pharmacology*
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Sulfonamides
Substances
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Amides
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Antiviral Agents
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Carbamates
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Cyclopropanes
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Macrocyclic Compounds
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Protease Inhibitors
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Quinoxalines
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Sulfonamides
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grazoprevir