Abstract
The tumor-suppressive activity of PTEN has always been attributed to its endogenous intracellular function. Recently two different groups have demonstrated that PTEN is secreted/exported into the extracellular environment for uptake by recipient cells, and functions as a tumor suppressor in a cell non-autonomous manner.
MeSH terms
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Exosomes / metabolism
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Gene Expression Regulation, Neoplastic
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Humans
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Mutation
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Neoplasms / genetics
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Neoplasms / metabolism*
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PTEN Phosphohydrolase / analysis
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PTEN Phosphohydrolase / genetics
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PTEN Phosphohydrolase / metabolism*
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Signal Transduction
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / metabolism*
Substances
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Tumor Suppressor Proteins
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PTEN Phosphohydrolase
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PTEN protein, human