A BINOL-based ratiometric fluorescent sensor for Zn2+ and in situ generated ensemble for selective recognition of histidine in aqueous solution

Analyst. 2013 Oct 7;138(19):5762-8. doi: 10.1039/c3an00979c.

Abstract

A novel BINOL-based ratiometric fluorescent sensor (R2) is presented, which can selectively respond to Zn(2+) over Cd(2+) and other metal ions with fluorescence enhancement in aqueous solution. The R2 was successfully applied in the imaging of Zn(2+) in living cells. Additionally, the in situ generated R2-Zn(II) ensemble could further serve as a probe to distinguish histidine from other amino acids via a displacement mode.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescent Dyes / chemical synthesis*
  • HeLa Cells
  • Histidine / analysis*
  • Histidine / metabolism
  • Humans
  • Naphthols / chemical synthesis*
  • Protein Binding / physiology
  • Solutions / analysis
  • Solutions / metabolism
  • Water / analysis*
  • Water / metabolism
  • Zinc / analysis*
  • Zinc / metabolism

Substances

  • BINOL, naphthol
  • Fluorescent Dyes
  • Naphthols
  • Solutions
  • Water
  • Histidine
  • Zinc