Mycophenolic acid morpholinoethylester (RS-61443) is a new immunosuppressant that prevents and halts heart allograft rejection by selective inhibition of T- and B-cell purine synthesis

Transplant Proc. 1990 Aug;22(4):1659-62.

Authors

R E Morris¹, E G Hoyt, M P Murphy, E M Eugui, A C Allison

Affiliation

¹ Department of Cardiovascular Surgery, Stanford University School of Medicine, CA 94305-5247.

PMID: 2389428

No abstract available

MeSH terms

Animals
B-Lymphocytes / drug effects*
B-Lymphocytes / immunology
B-Lymphocytes / metabolism
Cyclosporins / therapeutic use
Drug Therapy, Combination
Graft Rejection*
Graft Survival*
Heart Transplantation / immunology*
Immunosuppressive Agents / therapeutic use*
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mycophenolic Acid / analogs & derivatives*
Mycophenolic Acid / therapeutic use
Purines / antagonists & inhibitors
Purines / metabolism*
T-Lymphocytes / drug effects*
T-Lymphocytes / immunology
T-Lymphocytes / metabolism
Transplantation, Heterotopic
Transplantation, Homologous

Substances

Cyclosporins
Immunosuppressive Agents
Purines
Mycophenolic Acid