Peptide-based Targeting of Fluorescent Zinc Sensors to the Plasma Membrane of Live Cells

Chem Sci. 2013 Aug 1;4(8):3080-3084. doi: 10.1039/C3SC50974E.

Abstract

Combining fluorescent zinc sensors with the facile syntheses and biological targeting capabilities of peptides, we created green- and blue-emitting probes that, (i) are readily prepared on the solid-phase, (ii) retain the photophysical and zinc-binding properties of the parent sensor, and (iii) can be directed to the extracellular side of plasma membranes in live cells for detection of mobile zinc.