Animal models and measures of perceptual processing in schizophrenia

Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2092-8. doi: 10.1016/j.neubiorev.2013.06.016. Epub 2013 Jul 15.

Abstract

This paper summarizes the discussions regarding animal paradigms for assessing perception at the seventh meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS). A breakout group at the meeting addressed candidate tests in animals that might best parallel the human paradigms selected previously in the CNTRICS program to assess two constructs in the domain of perception: gain control and visual integration. The perception breakout group evaluated the degree to which each of the nominated tasks met pre-specified criteria: comparability of tasks across multiple species; construct validity; neuroanatomical homology between species; and dynamic range across parametric variation.

Keywords: Event related potentials; Mismatch negative; Prepulse inhibition of startle; Visual integration.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cognition Disorders / diagnosis
  • Cognition Disorders / etiology
  • Cognition Disorders / therapy
  • Disease Models, Animal*
  • Humans
  • Inhibition, Psychological
  • Nonlinear Dynamics
  • Perceptual Disorders / diagnosis*
  • Perceptual Disorders / etiology*
  • Photic Stimulation
  • Reproducibility of Results
  • Schizophrenia / complications*