Abstract
A novel angucycline-type antibiotic, warkmycin, was isolated from the culture filtrate of Streptomyces strain Acta 2930. Its chemical structure was elucidated by HR-MS, one-dimensional and 2D NMR experiments. The compound inhibits the growth of Gram-positive bacteria and shows a strong antiproliferative activity against mouse fibroblast cell line NIH-3T3 and human cancer cell lines HepG2 and HT29.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Benz(a)Anthracenes / chemistry
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Benz(a)Anthracenes / isolation & purification
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Benz(a)Anthracenes / pharmacology*
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Cell Proliferation / drug effects
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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Gram-Positive Bacteria / drug effects*
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HT29 Cells
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Hep G2 Cells
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Humans
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Magnetic Resonance Spectroscopy / methods
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Mass Spectrometry
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Mice
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NIH 3T3 Cells
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Streptomyces / metabolism*
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Trisaccharides / chemistry
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Trisaccharides / isolation & purification
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Trisaccharides / pharmacology*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Benz(a)Anthracenes
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Trisaccharides
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warkmycin