The use of iodine seed (I-125) as a marker for the localisation of lung nodules in minimal invasive pulmonary surgery

Eur J Surg Oncol. 2013 Sep;39(9):945-50. doi: 10.1016/j.ejso.2013.06.020. Epub 2013 Jul 10.

Abstract

Aim: Video assisted thoracic surgery (VATS) is an important tool in the field of thoracic pathology both for therapeutic and diagnostic purposes. The standard technique for localisation of non-visible or non-palpable lung lesions is the use of image guided insertion of a guide-wire. However, this method is associated with complications such as pneumothorax, bleeding and wire-dislocation. The aim of this study was to investigate the feasibility of using of iodine seeds (I-125) as a marker of lung lesions during VATS.

Methods: 28 consecutive patients with parenchymal lung lesions had I-125 seed localisation performed prior to VATS. After seed placement all patients underwent VATS with wedge resection.

Results: During surgery all lesions could be identified and radically resected. In six (21.4%) patients the seed was not placed optimally but none of these cases were associated with seed dislocation after placement. In four and in 5 patients the placement of the I-125 seed was complicated by a haematoma and pneumothorax respectively. However, in all of these patients a wait-and-see policy would have been justified. In one patient a conversion to a thoracotomy was necessary due to seed displacement.

Conclusion: In patients with parenchymal lung lesions undergoing VATS and wedge resection I-125 seed localisation is a feasible technique. Complication rates are comparable to standard guide-wire localisation. Although I-125 seeds can be positioned under CT-guidance an optimal placement is of utmost importance for VATS wedge resection. Further research is needed to investigate the possible advantages of this technique.

Keywords: Iodine seed; Localisation; Lung lesions; VATS.

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • Feasibility Studies
  • Female
  • Humans
  • Iodine Radioisotopes
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / surgery*
  • Male
  • Middle Aged
  • Multiple Pulmonary Nodules / diagnosis
  • Multiple Pulmonary Nodules / surgery*
  • Pneumonectomy / methods*
  • Radiography, Interventional
  • Solitary Pulmonary Nodule / diagnosis
  • Solitary Pulmonary Nodule / surgery*
  • Thoracic Surgery, Video-Assisted / instrumentation
  • Thoracic Surgery, Video-Assisted / methods*

Substances

  • Iodine Radioisotopes