Objective: The angiotensin-converting enzyme (ACE) may be involved in the pathogenesis of Parkinson's disease (PD). There have been several studies investigating the association between ACE gene I/D polymorphism and PD risk, but they reported inconsistent findings. We performed a meta-analysis to investigate the association between ACE gene I/D polymorphism and PD risk.
Methods: Published literature from PubMed and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using random- or fixed-effects models based on between-study heterogeneity.
Results: A total of five studies including 606 cases and 708 controls were finally included in the meta-analysis. Meta-analysis showed that there was no obvious association between ACE gene I/D polymorphism and PD risk under the homogeneous co-dominant model (OR = 1.14, 95% CI = 0.71-1.82), heterogeneous co-dominant model (OR = 0.92, 95% CI = 0.70-1.22), dominant model (OR = 0.99, 95% CI = 0.76-1.28) or recessive model (OR = 1.07, 95% CI = 0.83-1.37).
Conclusion: The meta-analysis suggests that there is no evidence for the association between ACE gene I/D polymorphism and PD risk.
Keywords: Angiotensin-converting enzyme; Parkinson’s disease; meta-analysis; polymorphism.
© The Author(s) 2013.