Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes

Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8210-2. doi: 10.1002/anie.201303544. Epub 2013 Jun 21.
No abstract available

Keywords: bioorthogonality; irreversible inhibitors; proteases; protein-templated reactions; ubiquitin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Alkynes / pharmacology*
  • Amides / chemistry*
  • Cysteine Proteases / chemistry*
  • Cysteine Proteases / metabolism*
  • Humans
  • Pargyline / analogs & derivatives*
  • Pargyline / pharmacology*
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology*

Substances

  • Alkynes
  • Amides
  • Protease Inhibitors
  • Pargyline
  • Cysteine Proteases