Suppression of interferon-mediated antiviral immunity by hepatitis B virus: an overview of research progress

Scand J Immunol. 2013 Sep;78(3):230-7. doi: 10.1111/sji.12086.

Abstract

Interferon (IFN)-α is an indispensable drug for hepatitis B treatment in clinical settings. However, hepatitis B virus (HBV) can attenuate IFN-mediated antiviral responses to avoid being inhibited or cleared. Much progress has been made in exploring how the IFN-induced anti-HBV effect is inhibited. This review examines and summarizes new advances regarding the molecular mechanism underlying the HBV-induced suppression of type I IFN-mediated antiviral immunity.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Hepatitis B / drug therapy*
  • Hepatitis B / immunology*
  • Hepatitis B virus / immunology*
  • Humans
  • Interferon-alpha / immunology
  • Interferon-alpha / metabolism
  • Interferon-alpha / therapeutic use*
  • Interferon-beta / immunology
  • Interferon-beta / metabolism
  • Signal Transduction

Substances

  • Antiviral Agents
  • Interferon-alpha
  • Interferon-beta