Copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagents

Org Lett. 2013 Jul 5;15(13):3326-9. doi: 10.1021/ol401362k. Epub 2013 Jun 21.

Abstract

The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Carboxylic Acids / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Indicators and Reagents / chemistry*
  • Methylation
  • Molecular Structure
  • Peroxides / chemistry*

Substances

  • Amides
  • Carboxylic Acids
  • Indicators and Reagents
  • Peroxides
  • Copper