A chemically reactive Raman probe for ultrasensitively monitoring and imaging the in vivo generation of femtomolar oxidative species as induced by anti-tumor drugs in living cells

Chem Commun (Camb). 2013 Jul 28;49(59):6647-9. doi: 10.1039/c3cc43410a.

Abstract

A chemically reactive Raman probe has been developed for ultrasensitively monitoring and imaging the in vivo generation of femtomolar oxidative species as induced by anti-tumor drugs in living cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Biosensing Techniques*
  • Cell Line, Tumor
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Metal Nanoparticles / chemistry
  • Molecular Structure
  • Polyethylene Glycols / chemistry
  • Reactive Oxygen Species / analysis*
  • Reactive Oxygen Species / metabolism*
  • Rhodamines / chemistry
  • Silver / chemistry
  • Spectrum Analysis, Raman

Substances

  • Antineoplastic Agents
  • Fluorescent Dyes
  • Reactive Oxygen Species
  • Rhodamines
  • dihydrorhodamine 123
  • Silver
  • Polyethylene Glycols