A parallelism between spectral grading and Gleason grading of malignant prostate tissues

V Masilamani; M S Alsalhi; S Devanesan; M Atif; D Rabah; K Farhat; Y Pu; R R Alfano

doi:10.1016/j.pdpdt.2012.12.002

A parallelism between spectral grading and Gleason grading of malignant prostate tissues

Photodiagnosis Photodyn Ther. 2013 May;10(2):168-72. doi: 10.1016/j.pdpdt.2012.12.002. Epub 2013 Jan 15.

Authors

V Masilamani¹, M S Alsalhi, S Devanesan, M Atif, D Rabah, K Farhat, Y Pu, R R Alfano

Affiliation

¹ Research Chair on Laser Diagnosis of Cancers, King Saud University, Riyadh, Saudi Arabia.

PMID: 23769283
DOI: 10.1016/j.pdpdt.2012.12.002

Abstract

Gleason score is the most common method of grading the virulence of prostate malignancy and is based on the pathological assessment of morphology of cellular matrix. Since this involves the excision of the tissue, we are working on a new, minimally invasive, non-contact, procedure of spectral diagnosis of prostate malignancy. In this preliminary in vitro study reported here, we have analyzed 27 tissue samples (normal control=7: benign=8: malignant=12) by Stokes' shift spectra (SSS) to establish a one-to-one correspondence between spectral grading and Gleason grading.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Diagnosis, Computer-Assisted / methods*
Humans
Male
Neoplasm Grading
Prostatic Neoplasms / pathology*
Reproducibility of Results
Sensitivity and Specificity
Spectrometry, Fluorescence / methods*