A new anti-cancer strategy of damaging mitochondria by pro-apoptotic peptide functionalized gold nanoparticles

Chem Commun (Camb). 2013 Jul 21;49(57):6403-5. doi: 10.1039/c3cc43283a.

Abstract

Gold nanoparticles functionalized with pro-apoptotic peptide (PAP-AuNPs) were fabricated, which were able to lead to programmed cell-death by damaging mitochondria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Apoptosis / drug effects
  • Gold / administration & dosage*
  • Gold / chemistry
  • HeLa Cells
  • Humans
  • Membrane Potential, Mitochondrial / drug effects
  • Metal Nanoparticles / administration & dosage*
  • Metal Nanoparticles / chemistry
  • Mitochondria / drug effects*
  • Mitochondria / physiology
  • Peptides / administration & dosage*
  • Peptides / chemistry

Substances

  • Antineoplastic Agents
  • Peptides
  • Gold