Abstract
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosome Deletion
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Chromosome Mapping
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Cloning, Molecular
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DNA-Binding Proteins / genetics
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Female
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Male
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Mice
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Molecular Sequence Data
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Mutation
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Nucleic Acid Hybridization
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Restriction Mapping
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Sequence Homology, Nucleic Acid
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Sex Determination Analysis*
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Testis / embryology*
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Testis / metabolism
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Y Chromosome*