MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells

FEBS Lett. 2013 Jul 11;587(14):2247-53. doi: 10.1016/j.febslet.2013.05.054. Epub 2013 Jun 4.

Abstract

Our study demonstrated the functions of microRNA-7 (miR-7) in cervical cancer. The overexpression of miR-7 in the cervical cancer cell lines HeLa and C-33A suppressed cell viability and promoted cell apoptosis, whereas the inhibition of miR-7 had opposite effects. Furthermore, an oncogene, X-linked inhibitor of apoptosis protein (XIAP), was identified as a new target of miR-7, and the ectopic expression of XIAP rescued the effects induced by miR-7 in HeLa and C-33A cells. These results indicate that miR-7 targeted and downregulated the oncogene XIAP to regulate the effect of miR-7 on apoptosis and malignant behaviors of HeLa and C-33A cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions
  • Apoptosis*
  • Base Sequence
  • Binding Sites
  • Cell Proliferation*
  • Cell Survival
  • Conserved Sequence
  • Down-Regulation
  • Female
  • Gene Expression Regulation, Neoplastic
  • HeLa Cells
  • Humans
  • MicroRNAs / physiology*
  • RNA Interference
  • Uterine Cervical Neoplasms
  • X-Linked Inhibitor of Apoptosis Protein / genetics*
  • X-Linked Inhibitor of Apoptosis Protein / metabolism

Substances

  • 3' Untranslated Regions
  • MIRN7 microRNA, human
  • MicroRNAs
  • X-Linked Inhibitor of Apoptosis Protein
  • XIAP protein, human