Synthesis of paclitaxel-conjugated β-cyclodextrin polyrotaxane and its antitumor activity

Angew Chem Int Ed Engl. 2013 Jul 8;52(28):7272-7. doi: 10.1002/anie.201301397. Epub 2013 Jun 5.

Authors

Shuling Yu¹, Yajun Zhang, Xin Wang, Xu Zhen, Zhaoheng Zhang, Wei Wu, Xiqun Jiang

Affiliation

¹ Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.

PMID: 23740531
DOI: 10.1002/anie.201301397

No abstract available

Keywords: antitumor agents; biodistribution; paclitaxel; polyrotaxanes; β-cyclodextrin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / administration & dosage
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / pharmacokinetics
Cell Line, Tumor
Cyclodextrins / chemistry*
Drug Carriers / chemistry*
Half-Life
Liver Neoplasms / drug therapy
Mice
Paclitaxel / administration & dosage
Paclitaxel / chemistry*
Poloxamer / chemistry*
Polymers / chemistry
Propylene Glycols / chemistry
Rotaxanes / chemistry*
Tissue Distribution
beta-Cyclodextrins / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Cyclodextrins
Drug Carriers
Polymers
Propylene Glycols
Rotaxanes
beta-Cyclodextrins
polyrotaxane
Poloxamer
polypropylene glycol
betadex
Paclitaxel