Analytical results on the Beauchemin model of lymphocyte migration

BMC Bioinformatics. 2013;14 Suppl 6(Suppl 6):S10. doi: 10.1186/1471-2105-14-S6-S10. Epub 2013 Apr 17.

Abstract

The Beauchemin model is a simple particle-based description of stochastic lymphocyte migration in tissue, which has been successfully applied to studying immunological questions. In addition to being easy to implement, the model is also to a large extent mathematically tractable. This article provides a comprehensive overview of both existing and new analytical results on the Beauchemin model within a common mathematical framework. Specifically, we derive the motility coefficient, the mean square displacement, and the confinement ratio, and discuss four different methods for simulating biased migration of pre-defined speed. The results provide new insight into published studies and a reference point for future research based on this simple and popular lymphocyte migration model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Movement*
  • Chemotaxis
  • Lymphocytes / cytology*
  • Models, Biological*