Increased glyoxalase-1 levels in Fkbp5 knockout mice caused by glyoxalase-1 gene duplication

Lorenz K Kollmannsberger; Nils C Gassen; Andrea Bultmann; Jakob Hartmann; Peter Weber; Mathias V Schmidt; Theo Rein

doi:10.1534/g3.113.006445

Increased glyoxalase-1 levels in Fkbp5 knockout mice caused by glyoxalase-1 gene duplication

G3 (Bethesda). 2013 Aug 7;3(8):1311-3. doi: 10.1534/g3.113.006445.

Authors

Lorenz K Kollmannsberger¹, Nils C Gassen, Andrea Bultmann, Jakob Hartmann, Peter Weber, Mathias V Schmidt, Theo Rein

Affiliation

¹ Max Planck Institute of Psychiatry, 80804 Munich, Germany.

Abstract

Fkbp5 is genetically linked to stress-related diseases. Fkbp5 knockout mice are available and widely used to explore the role of Fkbp5 in health and disease. We found that these mice carry a gene duplication of glyoxylase-1, which explains why glyoxylase-1 levels are increased in the Fkbp5 knockout mice.

Keywords: FKBP51; flanking gene problem; glyoxalase-1; knockout mice.

MeSH terms

Animals
Gene Duplication
HEK293 Cells
Hippocampus / metabolism
Humans
Lactoylglutathione Lyase / genetics*
Mice
Mice, Inbred C57BL
Mice, Knockout
Tacrolimus Binding Proteins / deficiency
Tacrolimus Binding Proteins / genetics*
Tacrolimus Binding Proteins / metabolism

Substances

Lactoylglutathione Lyase
Tacrolimus Binding Proteins
tacrolimus binding protein 5