Assembly of free-standing polypeptide films via the synergistic combination of hyperbranched macroinitiators, the grafting-from approach, and cross-chain termination

Steven Harris Wibowo; Edgar H H Wong; Adrian Sulistio; Stefanie N Guntari; Anton Blencowe; Frank Caruso; Greg G Qiao

doi:10.1002/adma.201301132

Assembly of free-standing polypeptide films via the synergistic combination of hyperbranched macroinitiators, the grafting-from approach, and cross-chain termination

Adv Mater. 2013 Sep 6;25(33):4619-24. doi: 10.1002/adma.201301132. Epub 2013 May 31.

Authors

Steven Harris Wibowo¹, Edgar H H Wong, Adrian Sulistio, Stefanie N Guntari, Anton Blencowe, Frank Caruso, Greg G Qiao

Affiliation

¹ Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, VIC 3010, Australia.

PMID: 23722350
DOI: 10.1002/adma.201301132

Abstract

Cross-linked polypeptide-based films are fabricated via a novel and robust method employing surface-initiated ring opening polymerization of α-amino acid N-carboxyanhydrides (NCA-ROP). The judicious combination of amine-based hyperbranched macroinitiators and benzyl ester-protected NCA derivatives promotes network formation by cross-chain terminations, which allows the formation of stable cross-linked peptide-based capsules in a one-pot system.

Keywords: N-carboxyanhydrides; cross-linked capsules; polypeptides; ring-opening polymerization; surface-initiated polymerization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry
Cross-Linking Reagents / chemical synthesis*
Cross-Linking Reagents / chemistry
Macromolecular Substances / chemistry
Models, Molecular
Particle Size
Peptides / chemical synthesis*
Peptides / chemistry
Polymerization
Silicon Dioxide / chemistry
Surface Properties

Substances

Amino Acids
Cross-Linking Reagents
Macromolecular Substances
Peptides
Silicon Dioxide