Rising from the crypt: decreasing DNA methylation during differentiation of the small intestine

Genome Biol. 2013 May 28;14(5):116. doi: 10.1186/gb-2013-14-5-116.

Abstract

The differentiation of intestinal stem cells involves few DNA methylation changes, assayed by bisulfite sequencing, in contrast to other adult somatic stem cell hierarchies.

Publication types

  • Comment

MeSH terms

  • Adult Stem Cells / metabolism*
  • Animals
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism*
  • Cell Differentiation*
  • Intestine, Small / cytology*
  • Transcription Factor 4

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Tcf4 protein, mouse
  • Transcription Factor 4