Adoptive T-cell transfer for refractory viral infections with cytomegalovirus, Epstein-Barr virus or adenovirus after allogeneic stem cell transplantation

J Feucht; L Joachim; P Lang; T Feuchtinger

doi:10.1055/s-0033-1333749

Adoptive T-cell transfer for refractory viral infections with cytomegalovirus, Epstein-Barr virus or adenovirus after allogeneic stem cell transplantation

Klin Padiatr. 2013 May;225(3):164-9. doi: 10.1055/s-0033-1333749. Epub 2013 May 22.

Authors

J Feucht¹, L Joachim, P Lang, T Feuchtinger

Affiliation

¹ Pediatric Hematology/Oncology, University Children's Hospital Tübingen, Germany.

PMID: 23700092
DOI: 10.1055/s-0033-1333749

Abstract

Viral infections after allogeneic stem cell transplantation (SCT) are an important cause of morbidity and mortality as SCT can expose patients to a transient state of combined immunodeficieny. Most viral infections after SCT are caused by the endogenous reactivation of persistent pathogens such as adenovirus (ADV), cytomegalovirus (CMV), and Epstein-Barr-virus (EBV). The control of these infections will ultimately depend on the restoration of adequate T-cell immunity.

MeSH terms

Adenoviridae Infections / immunology*
Adenoviridae Infections / therapy*
Adoptive Transfer*
Child
Cytomegalovirus Infections / immunology*
Cytomegalovirus Infections / therapy*
Epstein-Barr Virus Infections / immunology*
Epstein-Barr Virus Infections / therapy*
Follow-Up Studies
Hematopoietic Stem Cell Transplantation*
Humans
Opportunistic Infections / immunology*
Opportunistic Infections / therapy*
T-Lymphocytes / immunology*
Treatment Outcome