Punctate lesion pattern suggestive of perivascular inflammation in acute natalizumab-associated progressive multifocal leukoencephalopathy: productive JC virus infection or preclinical PML-IRIS manifestation?

J Neurol Neurosurg Psychiatry. 2013 Oct;84(10):1176-7. doi: 10.1136/jnnp-2013-304986. Epub 2013 May 21.

Authors

Mike P Wattjes, Lonneke Verhoeff, Willemijn Zentjens, Joep Killestein, Erik T van Munster, Frederik Barkhof, Jeroen J J van Eijk

PMID: 23695498
DOI: 10.1136/jnnp-2013-304986

No abstract available

Keywords: Infectious Diseases; MRI; Multiple Sclerosis.

Publication types

Letter

MeSH terms

Anti-Inflammatory Agents / therapeutic use
Antibodies, Monoclonal, Humanized / adverse effects*
Antibodies, Monoclonal, Humanized / therapeutic use
Brain / blood supply
Brain / pathology
Cerebral Arteries / pathology
Combined Modality Therapy
Diagnosis, Differential
Female
Humans
Image Enhancement
Image Interpretation, Computer-Assisted
Immune Reconstitution Inflammatory Syndrome / chemically induced*
Immune Reconstitution Inflammatory Syndrome / diagnosis*
Immune Reconstitution Inflammatory Syndrome / drug therapy
Infusions, Intravenous
Leukoencephalopathy, Progressive Multifocal / chemically induced*
Leukoencephalopathy, Progressive Multifocal / diagnosis*
Magnetic Resonance Imaging*
Methylprednisolone / therapeutic use
Middle Aged
Multiple Sclerosis, Relapsing-Remitting / diagnosis
Multiple Sclerosis, Relapsing-Remitting / drug therapy*
Natalizumab
Neurologic Examination / drug effects
Plasma Exchange

Substances

Anti-Inflammatory Agents
Antibodies, Monoclonal, Humanized
Natalizumab
Methylprednisolone