Abstract
Non-coding RNAs (ncRNAs) are increasingly recognized as central players in diverse biological processes. Upon DNA damage, the DNA damage response (DDR) elicits a complex signaling cascade, which includes the induction of multiple ncRNA species. Recent studies indicate that DNA-damage induced ncRNAs contribute to regulation of cell cycle, apoptosis and DNA repair, and thus play a key role in maintaining genome stability. This review summarizes the emerging role of ncRNAs in DNA damage and repair.
Published by Elsevier B.V.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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DNA Damage*
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DNA Repair Enzymes / genetics
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DNA Repair Enzymes / metabolism
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DNA Repair*
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Gene Expression
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Gene Expression Regulation
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Humans
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Intracellular Signaling Peptides and Proteins / genetics
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Intracellular Signaling Peptides and Proteins / metabolism
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Protein Processing, Post-Translational
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RNA, Untranslated / physiology*
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Signal Transduction
Substances
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Intracellular Signaling Peptides and Proteins
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RNA, Untranslated
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DNA Repair Enzymes