Well-defined Au-SiO(2)-CdTe composite nanoparticles were synthesized via a multistep chemical approach in water solution to gain insight into the interaction between metal and semiconductor nanostructures. Photoluminescence measurement reveals that the fluorescence of CdTe quantum dots (QDs) in this composite with optimized SiO(2) thickness (4 nm) has over ten times enhancement compared with that of bare CdTe QDs. The considerable fluorescence enhancement of CdTe QDs is attributed to the surface plasmon resonance, which is further confirmed by the lifetime measurement. The enhanced fluorescence can be used to improve the performance of CdTe QDs as fluorescence probe and may find potential applications in biolabeling.