Cephalosporin resistant Escherichia coli from cancer patients in Cairo, Egypt

Microbiol Immunol. 2013 May;57(5):391-5. doi: 10.1111/1348-0421.12046.

Abstract

Cephalosporin-resistant Escherichia coli has been increasingly reported worldwide. In this study, 32 cephalosporin resistant E. coli isolates identified from cancer patients in Cairo, Egypt in 2009-2010 were analyzed. Twenty-three were of phylogenetic group D, seven A and one each B1 and B2. By rep-PCR 15 phylogroup D isolates were grouped in four clusters, one with sequence type (ST) 405 and three ST68. Seventeen isolates showed single patterns. blaCTX-M-15 and aac(6')-Ib-cr were the most common resistance determinants. blaOXA-48 and blaVIM were also detected. Multidrug resistant E. coli seriously affects healthcare, especially in immunocompromised hosts, such as cancer patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Cephalosporins / pharmacology*
  • Child
  • Child, Preschool
  • Cluster Analysis
  • DNA, Bacterial / genetics
  • Egypt
  • Escherichia coli / classification
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / microbiology*
  • Genes, Bacterial
  • Genotype
  • Humans
  • Molecular Typing
  • Neoplasms / complications*
  • Polymerase Chain Reaction
  • Retrospective Studies
  • beta-Lactam Resistance*
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • DNA, Bacterial
  • beta-Lactamases