Osteomalacia induced by adefovir in patient with hepatitis B

Reumatol Clin. 2014 Mar-Apr;10(2):120-1. doi: 10.1016/j.reuma.2013.01.006. Epub 2013 May 8.
[Article in English, Spanish]

Abstract

Osteomalacia is defined as a defect in mineralization of the bone matrix. We describe the case of a patient with chronic hepatitis B infection in whom treatment with adefovir induced renal phosphate loss with intense and sustained hypophosphatemia which derived in symptomatic osteomalacia.

Keywords: Adefovir; Hipofosfatemia; Hypophosphatemia; Osteomalacia.

Publication types

  • Case Reports

MeSH terms

  • Adenine / adverse effects
  • Adenine / analogs & derivatives*
  • Adenine / therapeutic use
  • Aged, 80 and over
  • Antiviral Agents / adverse effects*
  • Antiviral Agents / therapeutic use
  • Hepatitis B, Chronic / complications
  • Hepatitis B, Chronic / drug therapy*
  • Humans
  • Male
  • Organophosphonates / adverse effects*
  • Organophosphonates / therapeutic use
  • Osteomalacia / chemically induced*
  • Osteomalacia / diagnosis

Substances

  • Antiviral Agents
  • Organophosphonates
  • adefovir
  • Adenine