Thermally controlled decarboxylative [4 + 2] cycloaddition between alkoxyoxazoles and acrylic acid: expedient access to 3-hydroxypyridines

Laurie-Anne Jouanno; Vincent Tognetti; Laurent Joubert; Cyrille Sabot; Pierre-Yves Renard

doi:10.1021/ol4010195

Thermally controlled decarboxylative [4 + 2] cycloaddition between alkoxyoxazoles and acrylic acid: expedient access to 3-hydroxypyridines

Org Lett. 2013 May 17;15(10):2530-3. doi: 10.1021/ol4010195. Epub 2013 May 6.

Authors

Laurie-Anne Jouanno¹, Vincent Tognetti, Laurent Joubert, Cyrille Sabot, Pierre-Yves Renard

Affiliation

¹ Normandie Université, COBRA, UMR 6014 & FR 3038; Université Rouen ; INSA Rouen; CNRS, 1 rue Tesnière 76821 Mont-Saint-Aignan, Cedex, France.

PMID: 23646924
DOI: 10.1021/ol4010195

Abstract

A modified Kondrat'eva cycloaddition involving an unprecedented thermally controlled metal-free decarboxylative aromatization affords an expedient access to natural 3-hydroxypyridine/piperidine systems.