Gold-catalyzed reactions between alkenyldiazo carbonyl species and acetals

J Org Chem. 2013 Jun 7;78(11):5711-6. doi: 10.1021/jo400419d. Epub 2013 May 14.

Abstract

In the presence of catalyst IPrAuSbF6 catalyst (IPr = 1,3-bis(diisopropylphenyl)imidazol-2-ylidene), alkenyldiazo carbonyl species react with organic acetals to give E-configured alkyl 3,5-dimethoxy-5-pent-2-enoates stereoselectively. This reaction sequence comprises an initial Prins-type reaction, followed by gold carbene formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetals / chemistry*
  • Azo Compounds / chemistry*
  • Catalysis
  • Molecular Structure
  • Organogold Compounds / chemistry*

Substances

  • Acetals
  • Azo Compounds
  • Organogold Compounds