Abstract
The epidermal growth factor receptor (EGFR) has a close relation to lung cancer; its role in the pathogenesis of lung cancer is to be further elucidated. The results of this study indicate that about 80% exosomes purified from the LC biopsies contained EGFR; only about 2% exosomes contained EGFR in the samples from chronic lung inflammation. The purified exosomes induced tolerogenic DCs. Coculture of the tolerogenic DCs and Th0 cells generated the tumor antigen-specific regulatory T cells (Treg). The Tregs could suppress the tumor antigen specific CD8+ T cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Neoplasm / immunology
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Antigens, Neoplasm / metabolism
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CD8-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / physiology
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Carcinoma, Non-Small-Cell Lung / immunology
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Carcinoma, Non-Small-Cell Lung / metabolism*
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Carcinoma, Non-Small-Cell Lung / pathology
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Case-Control Studies
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Cell Proliferation
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Cells, Cultured
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Coculture Techniques
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Dendritic Cells / immunology
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ErbB Receptors / metabolism*
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Exosomes / immunology
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Exosomes / metabolism*
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Humans
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Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism
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Lung Neoplasms / immunology
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Lung Neoplasms / metabolism*
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Lung Neoplasms / pathology
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Pneumonia / metabolism
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T-Lymphocytes, Regulatory / immunology*
Substances
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Antigens, Neoplasm
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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ErbB Receptors