Linking inflammation and neuroendocrine differentiation: the role of macrophage migration inhibitory factor-mediated signaling in prostate cancer

Rosalinda M Savoy; Paramita M Ghosh

doi:10.1530/ERC-13-0133

Linking inflammation and neuroendocrine differentiation: the role of macrophage migration inhibitory factor-mediated signaling in prostate cancer

Endocr Relat Cancer. 2013 May 21;20(3):C1-4. doi: 10.1530/ERC-13-0133. Print 2013 Jun.

Authors

Rosalinda M Savoy¹, Paramita M Ghosh

Affiliation

¹ Department of Urology, University of California Davis, Sacramento, California, USA.

PMID: 23612613
DOI: 10.1530/ERC-13-0133

Abstract

A new paper by Tawadros et al. in Endocrine-Related Cancer demonstrates a link between macrophage migration inhibitory factor and neuroendocrine differentiation in prostate cancer. This paper may have implications in explaining the effect of prostatitis and chronic inflammation on the development of aggressive prostate cancer.

Keywords: inflammation; macrophage migration inhibitory factor; neuroendocrine differentiation; prostate cancer; prostatitis.

Publication types

Comment

MeSH terms

Apoptosis*
Cell Differentiation*
Cell Proliferation*
Humans
Intramolecular Oxidoreductases / metabolism*
Macrophage Migration-Inhibitory Factors / metabolism*
Male
Neuroendocrine Cells / pathology*
Prostatic Neoplasms / pathology*

Substances

Macrophage Migration-Inhibitory Factors
Intramolecular Oxidoreductases