Abstract
We report here the self-assembly of a rationally designed paclitaxel drug amphiphile into well-defined supramolecular filaments that possess a fixed 41% paclitaxel loading. These filaments can exert effective cytotoxicity against a number of cell lines comparable to that of free paclitaxel.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Antineoplastic Agents, Phytogenic / administration & dosage
-
Antineoplastic Agents, Phytogenic / chemistry*
-
Cell Survival / drug effects
-
Drug Carriers / administration & dosage
-
Drug Carriers / chemistry*
-
Glutathione / chemistry
-
Humans
-
MCF-7 Cells
-
Microscopy, Electron, Transmission
-
Nanofibers / administration & dosage
-
Nanofibers / chemistry*
-
Nanofibers / ultrastructure
-
Oligopeptides / chemistry*
-
Paclitaxel / administration & dosage
-
Paclitaxel / chemistry*
-
tau Proteins / chemistry*
Substances
-
Antineoplastic Agents, Phytogenic
-
Drug Carriers
-
Oligopeptides
-
tau Proteins
-
Glutathione
-
Paclitaxel