Antibody-functionalized magnetic polymersomes: in vivo targeting and imaging of bone metastases using high resolution MRI

Adv Healthc Mater. 2013 Nov;2(11):1420-4. doi: 10.1002/adhm.201300061. Epub 2013 Apr 19.

Abstract

Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.

Keywords: bone tumor; magnetic resonance imaging; polymersome; targeting.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / metabolism*
  • Bone Neoplasms / diagnosis*
  • Bone Neoplasms / secondary*
  • Cell Line, Tumor
  • Ferric Compounds / chemistry
  • Humans
  • Magnetic Phenomena*
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Nanoparticles / chemistry
  • Polymers / chemistry*
  • Tissue Distribution

Substances

  • Antibodies
  • Ferric Compounds
  • Polymers
  • ferric oxide