Antibodies to interleukin 2 in sera of autoimmune-prone mice

Scand J Rheumatol. 1990;19(3):183-8. doi: 10.3109/03009749009095041.

Abstract

Autoimmune-prone mice spontaneously develop the disease characterized by autoantibodies to a wide variety of antigens. In the present study, we have demonstrated that IgG antibodies to interleukin 2 (IL-2) are to be found in serum of autoimmune mice in association with ageing. These antibodies can neutralize the biological activity of IL-2 and thus play an important role in the etiopathogenesis of autoimmune disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / immunology
  • Animals
  • Antibodies / analysis
  • Antibodies / immunology*
  • Autoimmune Diseases / etiology*
  • Disease Susceptibility
  • Female
  • Hybridization, Genetic
  • Immunoglobulin G / analysis
  • Interleukin-2 / immunology*
  • Mice
  • Mice, Inbred Strains / blood
  • Mice, Inbred Strains / physiology*
  • Rheumatoid Factor / analysis

Substances

  • Antibodies
  • Immunoglobulin G
  • Interleukin-2
  • Rheumatoid Factor