Copper-mediated, palladium-catalyzed cross-coupling of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate

J Org Chem. 2013 May 17;78(10):4850-6. doi: 10.1021/jo400412k. Epub 2013 Apr 30.

Abstract

The palladium-catalyzed cross-coupling reaction of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate in the presence of a copper mediator is reported. Under optimized conditions, all reactions worked well and provided difluoro-containing products in moderate to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Chromones / chemistry*
  • Copper / chemistry*
  • Cyclization
  • Fluoroacetates / chemical synthesis*
  • Fluoroacetates / chemistry*
  • Molecular Structure
  • Palladium / chemistry*
  • Quinolones / chemistry*

Substances

  • Chromones
  • Fluoroacetates
  • Quinolones
  • Palladium
  • Copper